Generic Asacol (Mesalamine)

Asacol is bowel-specific aminosalicylate drug to treat inflammation caused by ulcerative colitis, proctosigmoiditis, and proctitis.

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Description

Asacol Mesalamine OverView

Conventional Name: mesalamine (Asacol)

What is Asacol?

Asacol (mesalamine) influences a substance in the body that causes aggravation, tissue harm, and loose bowels.

Asacol HD deferred discharge 800mg tablets are utilized to treat tolerably dynamic ulcerative colitis in grown-ups.

Important Information

Call your primary care physician on the double on the off chance that you have extreme stomach torment, cramping, wicked loose bowels (may happen with fever, cerebral pain, and skin rash).

Before taking this medicine

You ought not to utilize Asacol HD in the event that you are adversely affected by mesalamine, headache medicine, sulfasalazine, or salicylates, (for example, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others).

To ensure Asacol HD is alright for you, tell your primary care physician on the off chance that you have:

a stomach condition called pyloric stenosis;

  • coronary illness;
  • kidney illness;
  • liver illness; or

a background marked by a blockage in your stomach related tract (stomach or digestive organs).

It isn’t known whether Asacol HD will hurt an unborn infant.

Try not to offer this medication to a kid without therapeutic guidance.

How should I take mesalamine?

Take Asacol HD precisely as recommended by your PCP. Pursue all bearings on your medicine name.

Take the tablets with glass of water.

Take Asacol HD deferred discharge 800mg tablets on an unfilled stomach, in any event, 1 hour prior and 2 hours after a feast. Adhere to your PCP’s guidelines or the headings on your prescription mark.

Try not to pound, break, or bite a deferred discharge tablet. Gulp down the tablet.

The enteric-covered tablet has an extraordinary covering to ensure your stomach. Breaking the tablet could harm this covering.

 

Call your primary care physician if your ulcerative colitis side effects don’t improve, or in the event that they deteriorate.

 

evade while taking Asacol HD?

Ask your primary care physician before utilizing an acid neutralizer, and utilize just the sort your PCP suggests. A few acid neutralizers can make it harder for your body to retain mesalamine.

Asacol reactions

  • serious stomach torment, cramping, wicked looseness of the bowels;
  • fever, cerebral pain, skin rash;
  • wicked or falter stools, hacking up blood or regurgitation that resembles espresso beans;
  • kidney issues – practically no pee, agonizing or troublesome pee, swelling in your feet or lower legs, feeling worn out or shy of breath; or
  • liver issues – loss of hunger, upper stomach torment, tiredness, simple wounding or dying,

Basic Asacol HD reactions may include:

  • queasiness, stomach torment, the runs, stoppage;
  • runny or stuffy nose, sinus torment, sore throat;
  • influenza-like side effects;
  • cerebral pain, back torment;
  • rash; or
  • irregular liver capacity tests.

What different medications will influence Asacol HD?

Enlighten your primary care physician concerning all your present prescriptions and any you begin or quit utilizing, particularly:

  • azathioprine;
  • mercaptopurine; or

NSAIDs (nonsteroidal mitigating drugs) – headache medicine, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This rundown isn’t finished. Different medications may interface with mesalamine, including solution and over-the-counter prescriptions, nutrients, and natural items. Not every conceivable collaboration are recorded in this prescription guide.

Reactions

Less Common

  • Obscured vision
  • tipsiness
  • fever
  • full or enlarged inclination
  • migraine (extreme)
  • tingling, skin rash
  • apprehension
  • beating in the ears
  • weight in the stomach
  • slow or quick heartbeat
  • stomach issues (extreme)
  • swelling of the stomach or stomach territory
  • strange tiredness or shortcoming

Uncommon

  • Nervousness
  • back torment (extreme)
  • blue or fair skin
  • chest torment, perhaps moving to one sidearm, neck, or shoulder
  • chills
  • queasiness
  • spewing
  • yellow eyes or skin
  • Mesalamine Pregnancy Warnings

Mesalamine Pregnancy Warnings

Creature studies did not indicate embryotoxicity or teratogenicity, aside from at maternotoxic dosages. Human information are restricted. Mesalamine crosses the placenta. Constrained distributed human information demonstrate no expansion in the general pace of innate abnormalities. A few information demonstrate an expanded pace of preterm birth, stillbirth, and low birth weight; in any case, these antagonistic pregnancy results are likewise connected with dynamic incendiary inside sickness. Blood issue (leucopenia, thrombocytopenia, iron deficiency) have been accounted for in infants of moms being treated with mesalamine. There has been one case report of renal disappointment in an infant uncovered during the third and fifth month of pregnancy. There is no controlled information in human pregnancy.

Non-steroidal mitigating medications repress prostaglandin amalgamation and, when given during the last piece of pregnancy, may cause conclusion of the fetal ductus arteriosus, fetal renal hindrance, restraint of platelet collection, and postpone work and birth. Consistent treatment with non-steroidal mitigating drugs during the last trimester of pregnancy should just be given on sound signs. During the most recent couple of days before anticipated birth, maintain a strategic distance from specialists with an inhibitory impact on prostaglandin union.

Dibutyl phthalate (DBP) is an inert fixing in the US Asacol(R) and Asacol HD(R’s) enteric covering, and in creature contemplates maternal DBP was related with outside and skeletal contortions and unfriendly impacts on the male conceptive framework.

AU TGA pregnancy classification C: Drugs which, attributable to their pharmacological impacts, have caused or might be associated with causing, destructive consequences for the human hatchling or neonate without causing abnormalities. These impacts might be reversible. Going with writings ought to be counselled for further subtleties.

US FDA pregnancy classification B: Animal generation studies have neglected to exhibit a hazard to the hatchling and there are no sufficient and well-controlled examinations in pregnant ladies.

US FDA pregnancy classification C: Animal multiplication studies have demonstrated an unfriendly impact on the baby and there are no satisfactory and well-controlled examinations in people,

Use is suggested just if unmistakably required and the advantage exceeds the hazard.

Mesalamine Breastfeeding Warnings

Use with alert; advantage to mother ought to exceed hazard to the newborn child.

Discharged into human milk: Yes

Remarks:

– If the newborn child creates looseness of the bowels, suspend breastfeeding.

Creature studies did not demonstrate unfriendly impacts on the posterity during lactation. There is a case report of a newborn child with watery looseness of the bowels that settled when the mother halted mesalamine, which returned with rechallenge.

Following the oral organization of mesalamine, the milk to plasma proportion ranges from 0.1 to 0.3. The milk to plasma proportion of N-acetyl-5-aminosalicylic corrosive extents from 5.1 to 16.5.

In distributed lactation examines, maternal mesalamine dosages from different oral and rectal definitions and items went from 500 mg to 3 g day by day. The centralizations of mesalamine and N-acetyl-5-aminosalicylic corrosive in milk went from nondetectable to 0.11 mg/L and 5 to 18.1 mg/L, individually. In view of these fixations, assessed newborn child day by day portions for an only breastfed baby are 0 to 0.017 mg/kg/day of mesalamine and 0.75 to 2.72 mg/kg/day of N-acetyl-5-aminosalicylic corrosive.

Dibutyl phthalate, an inert fixing in the enteric covering of Asacol(R) and Asacol(R) HD tablets, and its essential metabolite mono-butyl phthalate are discharged into human milk. The clinical centrality has not been built up.

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